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This maturation medium contained a specific small-molecule cocktail: 5 A8301, 0.1 dexamethasone (Dex), 0.1 M Dihexa, and 0.5 mM NH4Cl

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they are research observations in laboratory models

Disclosure of interest: Name of author: nothing to disclose

The location has nothing to do with the injury site

Intriguingly, MRI evidence of BBB disruption has been noted in seemingly normal white matter even before the emergence of enhancing lesions, as well as in non-enhancing regions, implying that BBB impairment precedes both clinical symptoms and other MRI-evident changes in the disease course